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Image Search Results
Journal: Advanced Science
Article Title: Gastrointestinal Incomplete Degradation Exacerbates Neurotoxic Effects of PLA Microplastics via Oligomer Nanoplastics Formation
doi: 10.1002/advs.202401009
Figure Lengend Snippet: Stabilizing mitochondrial calcium levels ameliorates PLA MP‐induced PD‐like neurodegeneration in mice. A) Treatment strategy and experimental design overview. B) Relative mitochondrial calcium concentration and C) relative ATP content in midbrains after consecutive 28 days of exposure to PLA polymer MPs while treated with MCU‐i4 or DBcAMP. D) Activity levels in the open field test. E) Grip strength assessed in the grip strength test. F) Latency time measured in the rotarod test. G) Representative images of Nissl staining, TH staining, and TUNEL staining in mouse midbrains. Relative percentages of positive staining in midbrain cells for H) Nissl staining, I) TH staining, and J) TUNEL staining. Statistical analyses are determined by ANOVA, followed by Tukey's multiple comparison tests; * p < 0.05. ANOVA, analysis of variance; Micu3 , mitochondrial calcium uptake family member 3; MPs, microplastics; PLA, polylactic acid. TH, tyrosine hydroxylase; TUNEL, TdT‐mediated dUTP nick‐end labeling.
Article Snippet:
Techniques: Concentration Assay, Polymer, Activity Assay, Staining, TUNEL Assay, Comparison, End Labeling